From the Blog

Review of Phoenix QT+, a thorough QT analysis tool

This is a review of the Phoenix® QT+™ module that can be used within the Phoenix® platform to analyze ECG and concentration-time data from Phase 1, thorough QT (TQT) clinical studies, and phase 2/3 ECG sub-studies. Before diving into the review, I would like to give a brief background on thorough QT clinical studies. Regulatory […]

Extrapolating AUC to infinity

Area under the curve or AUC is a pharmacokinetic statistic used to describe the total exposure to a drug. More specifically, it is the time-averaged concentration of drug circulating in the body fluid analyzed (normally plasma, blood or serum). Standard calculation of AUC involves using noncompartmental techniques to calculate the AUC from time 0 to […]

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