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Calculating the elimination rate constant

The elimination rate constant is the rate at which drug is cleared from the body assuming first-order elimination. Various abbreviations are used to represent the elimination rate constant including ke, kel, λ, and λz. The calculation of the elimination rate constant can be done using pharmacokinetic parameters or it can be done directly from a […]

Errors in Kinetica Software … What is the impact?

A recent publication in the AAPS Journal by Helmut Schütz, Detlew Labes, and Anders Fuglsang (link) discussed difficulties in validating statistical software packages. They said: The purpose of this paper is therefore to introduce reference datasets of varying complexity in terms of dataset size and characteristics (balance, range, outlier presence, residual error distribution) for 2-treatment, 2-period, 2-sequence […]

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